This group of research was created in 2011. It includes some members of the former LICAS Group- Faculty of Exact and Natural Sciences- UNMDP directed by Dr. Víctor J. Moreno  and Dra. Julia E. A. de Moreno. Our group is interested on aquatic ecotoxicology, focusing on effects at biochemical and genetic level in aquatic non target organisms exposed to organic pollutants, like current- use pesticides.

Monitoring of aquatic pollution
Biochemical biomarkers (detoxication and antioxidant enzymes, endogenous metabolites)
Biomarkers of genotoxicity (cytogenetic and molecular)
Molecular biomarkers (isoenzyme expression)

Director
Dra. Mirta L. Menone
Researcher CONICET .

Professor

Negro, C. L., Iturburu, F. G., Mendieta, J., Menone, M. L., & Collins, P. (2019). Are oxidative stress biomarkers sensitive to environmental concentrations of chlorpyrifos exposed to the freshwater crab, Zilchiopsis collastinensis (Decapoda; Trichodactylidae)? Bulletin of Environmental Contamination and Toxicology, 103(3), 405–410. https://doi.org/10.1007/s00128-019-02643-9
Moreyra, L. D., Garanzini, D. S., Medici, S., & Menone, M. L. (2019). Evaluation of growth, photosynthetic pigments and genotoxicity in the wetland macrophyte Bidens laevis exposed to tebuconazole. Bulletin of Environmental Contamination and Toxicology, 102(3), 353–357. https://doi.org/10.1007/s00128-019-02539-8
Garanzini, D. S., Medici, S., Moreyra, L. D., & Menone, M. L. (2019). Acute exposure to a commercial formulation of Azoxystrobin alters antioxidant enzymes and elicit damage in the aquatic macrophyte Myriophyllum quitense. Physiology and Molecular Biology of Plants, 25(1), 135–143. https://doi.org/10.1007/s12298-018-0603-7
Lukaszewicz, G., Amé, M. V., & Menone, M. L. (2018). Selection of reference genes for reverse transcription-qPCR analysis in the biomonitor macrophyte <Emphasis Type="Italic">Bidens laevis</Emphasis> L. Physiology and Molecular Biology of Plants, 24(5), 781–792. https://doi.org/10.1007/s12298-018-0534-3
Iturburu, F. G., Simoniello, M. F., Medici, S., Panzeri, A. M., & Menone, M. L. (2018). Imidacloprid causes DNA damage in fish: clastogenesis as a mechanism of genotoxicity. Bulletin of Environmental Contamination and Toxicology, 100(6), 760–764. https://doi.org/10.1007/s00128-018-2338-0
Iturburu, F. G., Bertrand, L., Mendieta, J. R., Amé, M. V., & Menone, M. L. (2018). An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid. Ecological Indicators, 93, 351–357. https://doi.org/10.1016/j.ecolind.2018.05.019
Crupkin, A. C., Iturburu, F. G., Crupkin, M., & Menone, M. L. (2018). Myofibrilar functional dysregulation in fish: A new biomarker of damage to pesticides. Ecotoxicology and Environmental Safety, 158, 44–49. https://doi.org/10.1016/j.ecoenv.2018.03.096
Pérez, D. J., Okada, E., Menone, M. L., & Costa, J. L. (2017). Can an aquatic macrophyte bioaccumulate glyphosate? Development of a new method of glyphosate extraction in Ludwigia peploides and watershed scale validation. Chemosphere, 185, 975–982. https://doi.org/10.1016/j.chemosphere.2017.07.093
Iturburu, F. G., Zömisch, M., Panzeri, A. M., Crupkin, A. C., Contardo-Jara, V., Pflugmacher, S., & Menone, M. L. (2017). Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus. Environmental Toxicology and Chemistry, 36(3), 699–708. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/etc.3574/full
Débora J. Pérez, Lukaszewicz, G., Menone, M. L., Amé, M. V., & Camadro, E. L. (2014). Genetic and biochemical biomarkers in the macrophyte Bidens laevis L. exposed to a commercial formulation of endosulfan. Environmental Toxicology, 29(9), 1063–1071. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/tox.21836/full
Menone, M. L., Pérez, D. J., Lukaszewicz, G., & Camadro, E. L. (2015). Identificación de hidrófitas dulceacuícolas para estudios de genotoxicidad de contaminantes acuáticos. Journal of Basic and Applied Genetics, 26(1), 9–17. Retrieved from http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332015000100002
Garanzini, D. S., & Menone, M. L. (2015). Azoxystrobin causes oxidative stress and DNA damage in the aquatic macrophyte Myriophyllum quitense. Bulletin of Environmental Contamination and Toxicology, 94(2), 146–151. Retrieved from http://link.springer.com/article/10.1007/s00128-014-1428-x
Crupkin, A. C., Carriquiriborde, P., Mendieta, J., Panzeri, A. M., Ballesteros, M. L., Miglioranza, K. S., & Menone, M. L. (2013). Oxidative stress and genotoxicity in the South American cichlid, Australoheros facetus, after short-term sublethal exposure to endosulfan. Pesticide Biochemistry and Physiology, 105(2), 102–110. Retrieved from http://www.sciencedirect.com/science/article/pii/S0048357512001861
Salvio, C., Manetti, P. L., Clemente, N. L., Menone, M. L., & López, A. N. (2015). Toxicidad subletal de clorpirifos sobre Octolasion cyaneum (Annelida: Oligochaeta, Lumbricidae). Agriscientia, 32(2), 131–138. Retrieved from http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1668-298X2015000200006
Crupkin, A. C., & Menone, M. L. (2013). Changes in the activities of glutathione-S-transferases, glutathione reductase and catalase after exposure to different concentrations of cadmium in Australoheros facetus (Cichlidae, Pisces). Ecotoxicology and Environmental Contamination, 8(1), 21–25. Retrieved from http://siaiap32.univali.br/seer/index.php/eec/article/view/3152
Researchers
Dra. Andrea C. Crupkin
Professor

Researcher (CIC)

Crupkin, A. C., Iturburu, F. G., Crupkin, M., & Menone, M. L. (2018). Myofibrilar functional dysregulation in fish: A new biomarker of damage to pesticides. Ecotoxicology and Environmental Safety, 158, 44–49. https://doi.org/10.1016/j.ecoenv.2018.03.096
Iturburu, F. G., Zömisch, M., Panzeri, A. M., Crupkin, A. C., Contardo-Jara, V., Pflugmacher, S., & Menone, M. L. (2017). Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus. Environmental Toxicology and Chemistry, 36(3), 699–708. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/etc.3574/full
Crupkin, A. C., Carriquiriborde, P., Mendieta, J., Panzeri, A. M., Ballesteros, M. L., Miglioranza, K. S., & Menone, M. L. (2013). Oxidative stress and genotoxicity in the South American cichlid, Australoheros facetus, after short-term sublethal exposure to endosulfan. Pesticide Biochemistry and Physiology, 105(2), 102–110. Retrieved from http://www.sciencedirect.com/science/article/pii/S0048357512001861
Crupkin, A. C., & Menone, M. L. (2013). Changes in the activities of glutathione-S-transferases, glutathione reductase and catalase after exposure to different concentrations of cadmium in Australoheros facetus (Cichlidae, Pisces). Ecotoxicology and Environmental Contamination, 8(1), 21–25. Retrieved from http://siaiap32.univali.br/seer/index.php/eec/article/view/3152
Lic. Ana M. Panzeri
Teaching Assistant
Iturburu, F. G., Simoniello, M. F., Medici, S., Panzeri, A. M., & Menone, M. L. (2018). Imidacloprid causes DNA damage in fish: clastogenesis as a mechanism of genotoxicity. Bulletin of Environmental Contamination and Toxicology, 100(6), 760–764. https://doi.org/10.1007/s00128-018-2338-0
Iturburu, F. G., Zömisch, M., Panzeri, A. M., Crupkin, A. C., Contardo-Jara, V., Pflugmacher, S., & Menone, M. L. (2017). Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus. Environmental Toxicology and Chemistry, 36(3), 699–708. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/etc.3574/full
Crupkin, A. C., Carriquiriborde, P., Mendieta, J., Panzeri, A. M., Ballesteros, M. L., Miglioranza, K. S., & Menone, M. L. (2013). Oxidative stress and genotoxicity in the South American cichlid, Australoheros facetus, after short-term sublethal exposure to endosulfan. Pesticide Biochemistry and Physiology, 105(2), 102–110. Retrieved from http://www.sciencedirect.com/science/article/pii/S0048357512001861
Dra. Débora J. Pérez
Researcher CONICET
Débora J. Pérez, Lukaszewicz, G., Menone, M. L., Amé, M. V., & Camadro, E. L. (2014). Genetic and biochemical biomarkers in the macrophyte Bidens laevis L. exposed to a commercial formulation of endosulfan. Environmental Toxicology, 29(9), 1063–1071. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/tox.21836/full
Graduate Students
Dr. Germán Lukaszewicz
Postdoctoral Fellow
Lukaszewicz, G., Amé, M. V., & Menone, M. L. (2018). Selection of reference genes for reverse transcription-qPCR analysis in the biomonitor macrophyte <Emphasis Type="Italic">Bidens laevis</Emphasis> L. Physiology and Molecular Biology of Plants, 24(5), 781–792. https://doi.org/10.1007/s12298-018-0534-3
García, C. F., Pedrini, N., Sánchez-Paz, A., Reyna-Blanco, C. S., Lavarias, S., Muhlia-Almazán, A., … Sotelo-Mundo, R. R. (2018). De novo assembly and transcriptome characterization of the freshwater prawn Palaemonetes argentinus: Implications for a detoxification response. Marine Genomics, 37, 74–81. https://doi.org/10.1016/j.margen.2017.08.009
Débora J. Pérez, Lukaszewicz, G., Menone, M. L., Amé, M. V., & Camadro, E. L. (2014). Genetic and biochemical biomarkers in the macrophyte Bidens laevis L. exposed to a commercial formulation of endosulfan. Environmental Toxicology, 29(9), 1063–1071. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/tox.21836/full
Menone, M. L., Pérez, D. J., Lukaszewicz, G., & Camadro, E. L. (2015). Identificación de hidrófitas dulceacuícolas para estudios de genotoxicidad de contaminantes acuáticos. Journal of Basic and Applied Genetics, 26(1), 9–17. Retrieved from http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332015000100002
Dra. Daniela S. Garanzini
Postdoctoral  Fellow
Moreyra, L. D., Garanzini, D. S., Medici, S., & Menone, M. L. (2019). Evaluation of growth, photosynthetic pigments and genotoxicity in the wetland macrophyte Bidens laevis exposed to tebuconazole. Bulletin of Environmental Contamination and Toxicology, 102(3), 353–357. https://doi.org/10.1007/s00128-019-02539-8
Garanzini, D. S., Medici, S., Moreyra, L. D., & Menone, M. L. (2019). Acute exposure to a commercial formulation of Azoxystrobin alters antioxidant enzymes and elicit damage in the aquatic macrophyte Myriophyllum quitense. Physiology and Molecular Biology of Plants, 25(1), 135–143. https://doi.org/10.1007/s12298-018-0603-7
Garanzini, D. S., & Menone, M. L. (2015). Azoxystrobin causes oxidative stress and DNA damage in the aquatic macrophyte Myriophyllum quitense. Bulletin of Environmental Contamination and Toxicology, 94(2), 146–151. Retrieved from http://link.springer.com/article/10.1007/s00128-014-1428-x
Lic. Fernando G. Iturburu
Doctoral Fellow
Negro, C. L., Iturburu, F. G., Mendieta, J., Menone, M. L., & Collins, P. (2019). Are oxidative stress biomarkers sensitive to environmental concentrations of chlorpyrifos exposed to the freshwater crab, Zilchiopsis collastinensis (Decapoda; Trichodactylidae)? Bulletin of Environmental Contamination and Toxicology, 103(3), 405–410. https://doi.org/10.1007/s00128-019-02643-9
Iturburu, F. G., Simoniello, M. F., Medici, S., Panzeri, A. M., & Menone, M. L. (2018). Imidacloprid causes DNA damage in fish: clastogenesis as a mechanism of genotoxicity. Bulletin of Environmental Contamination and Toxicology, 100(6), 760–764. https://doi.org/10.1007/s00128-018-2338-0
Iturburu, F. G., Bertrand, L., Mendieta, J. R., Amé, M. V., & Menone, M. L. (2018). An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid. Ecological Indicators, 93, 351–357. https://doi.org/10.1016/j.ecolind.2018.05.019
Crupkin, A. C., Iturburu, F. G., Crupkin, M., & Menone, M. L. (2018). Myofibrilar functional dysregulation in fish: A new biomarker of damage to pesticides. Ecotoxicology and Environmental Safety, 158, 44–49. https://doi.org/10.1016/j.ecoenv.2018.03.096
Iturburu, F. G., Zömisch, M., Panzeri, A. M., Crupkin, A. C., Contardo-Jara, V., Pflugmacher, S., & Menone, M. L. (2017). Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus. Environmental Toxicology and Chemistry, 36(3), 699–708. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/etc.3574/full
Lic. Jésica Yamila Gotte Hirschfeld
Doctoral Fellow