The general objective of our research group is to carry out studies on phenotypic flexibility at the biochemical and physiological level in key organisms from coastal environments. Within the general objective, we carried out integrative and comparative studies on digestive and metabolic biochemical physiology and on mechanisms of adjustment at the biochemical-physiological level in relation to key environmental variables as well as  on the pathways and regulatory mechanisms involved.

Integrative and comparative studies on enzymatic activities involved in adjustments to changes in key environmental variables and on pathways and regulatory mechanisms involved

Studies of characterization and of modulation by different pathways of key enzymes in the digestive tract and of energy reserves.

Director
Dra. Alejandra López
Professor

Researcher CONICET

Researchers
Dra. Silvina Pinoni
Researcher CONICET
Pinoni, S. A., Jerez-Cepa, I., López Mañanes, A. A., & Romero, J. M. M. (2018). The euryhaline crab Uca tangeri showed metabolic differences to sex and environmental salinity. Journal of the Marine Biological Association of the United Kingdom, 98(6), 1465–1475. https://doi.org/10.1017/S0025315417000601
Pinoni, S. A., & López Mañanes, A. A. (2016). Digestive flexibility in the euryhaline crab Cyrtograpsus angulatus (Decapoda, Brachyura, Varunidae) from Mar Chiquita coastal lagoon (Buenos Aires, Argentina): responses to salinity of key enzymes in hepatopancreas. Pan-American Journal of Aquatic Sciences, 11(4), 345–355. Retrieved from http://www.panamjas.org/pdf_artigos/PANAMJAS_11(4)_345-355.pdf
Pinoni, S. A., Méndez, E., & López Mañanes, A. A. (2015). Digestive flexibility in a euryhaline crab from a SW Atlantic coastal lagoon: alkaline phosphatase activity sensitive to salinity in the hepatopancreas. Journal of the Marine Biological Association of the United Kingdom, 95(06), 1133–1140.
Pinoni, S. A., Michiels, M. S., & López Mañanes, A. A. (2013). Phenotypic flexibility in response to environmental salinity in the euryhaline crab Neohelice granulata from the mudflat and the saltmarsh of a SW coastal lagoon. Marine Biology, 160(10), 2647–2661.
Graduate Students
Dra. Antonela Asaro
Postdoctoral Fellow
Asaro, A., Martos-Sitcha, J. A., Martínez-Rodríguez, G., Mancera, J. M., & López Mañanes, A. (2018). In silico analysis and effects of environmental salinity in the expression and activity of digestive α-amylase and trypsins from the euryhaline crab Neohelice granulata. Canadian Journal of Zoology, 96(2), 127–139. https://doi.org/10.1139/cjz-2016-0324
Asaro, A., Paggi, R. A., del Valle, J. C., & López Mañanes, A. A. (2018). Glucose homeostasis in the euryhaline crab Cytograpsus angulatus: Effects of the salinity in the amylase, maltase and sucrase activities in the hepatopancreas and in the carbohydrate reserves in different tissues. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 216, 39–47. https://doi.org/10.1016/j.cbpb.2017.11.012
Postdoctoral Fellow
Del Valle, J. C., Michiels, M. S., Radonic, M., López, A., & López Mañanes, A. A. (2016). Digestive and metabolic profile at the biochemical level of juvenile flounder Paralichthys orbignyanus (Valenciennes, 1839) (Pleuronectiformes: Paralichthyidae). Pan-American Journal of Aquatic Sciences, 11(4), 309–323. Retrieved from http://www.panamjas.org/pdf_artigos/PANAMJAS_11(4)_309-323.pdf
Michiels, M. S., del Valle, J. C., & López Mañanes, A. A. (2013). Effect of environmental salinity and dopamine injections on key digestive enzymes in hepatopancreas of the euryhaline crab Cyrtograpsus angulatus (Decapoda: Brachyura: Varunidae. Scientia Marina, 77(1), 129–136. Retrieved from http://ri.conicet.gov.ar/handle/11336/2234
Pinoni, S. A., Michiels, M. S., & López Mañanes, A. A. (2013). Phenotypic flexibility in response to environmental salinity in the euryhaline crab Neohelice granulata from the mudflat and the saltmarsh of a SW coastal lagoon. Marine Biology, 160(10), 2647–2661.
Michiels, M. S., del Valle, J. C., & López Mañanes, A. A. (2017). Trypsin and N-aminopeptidase (APN) activities in the hepatopancreas of an intertidal euryhaline crab: Biochemical characteristics and differential modulation by histamine and salinity. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 204, 228–235.
Michiels, M. S., del Valle, J. C., & López Mañanes, A. A. (2015). Lipase activity sensitive to dopamine, glucagon and cyclic AMP in the hepatopancreas of the euryhaline burrowing crab Neohelice granulata (Dana, 1851)(Decapoda, Grapsidae). Crustaceana, 88(1), 51–65. Retrieved from http://booksandjournals.brillonline.com/content/journals/10.1163/15685403-00003399
Michiels, M. S., Del Valle, J. C., & López Mañanes, A. A. (2015). Biochemical characteristics and modulation by external and internal factors of aminopeptidase-N activity in the hepatopancreas of a euryhaline burrowing crab. Journal of Comparative Physiology B, 185(5), 501–510. Retrieved from http://link.springer.com/article/10.1007/s00360-015-0899-3
Doctoral Fellow
Méndez, E., Caruso Neves, C., & López Mañanes, A. (2018). Two sodium pumps in the hepatopancreas of the intertidal euryhaline crab Neohelice granulata: biochemical characteristics and differential modulation after feeding. Canadian Journal of Zoology, 96(6), 576–584. https://doi.org/10.1139/cjz-2017-0128
Pinoni, S. A., Méndez, E., & López Mañanes, A. A. (2015). Digestive flexibility in a euryhaline crab from a SW Atlantic coastal lagoon: alkaline phosphatase activity sensitive to salinity in the hepatopancreas. Journal of the Marine Biological Association of the United Kingdom, 95(06), 1133–1140.