El objetivo general de nuestro grupo de investigación es realizar estudios sobre flexibilidad fenotípica a nivel bioquímico-fisiológico en organismos de ambientes costeros. Dentro del objetivo general, llevamos a cabo estudios integrativos y comparativos sobre fisiología bioquímica digestiva y metabólica y sobre mecanismos de ajuste a nivel bioquímico-fisiológico en relación a variables ambientales clave y sobre vías y mecanismos de regulación implicados.

  • Estudios integrativos y comparativos sobre actividades enzimáticas implicadas en ajustes a corto y largo plazo a cambios en variables ambientales clave y sobre las posibles vías y mecanismos de regulación implicados.
  • Estudios de caracterización y modulación por diferentes vías de enzimas digestivas y reservas de energía.
Director
Dra. Alejandra López
Profesora adjunta Fisiología General UNMDP .

Investigador independiente CONICET

Pinoni, S. A., Jerez-Cepa, I., López Mañanes, A. A., & Romero, J. M. M. (2018). The euryhaline crab Uca tangeri showed metabolic differences to sex and environmental salinity. Journal of the Marine Biological Association of the United Kingdom, 98(6), 1465–1475. https://doi.org/10.1017/S0025315417000601
Méndez, E., Caruso Neves, C., & López Mañanes, A. (2018). Two sodium pumps in the hepatopancreas of the intertidal euryhaline crab Neohelice granulata: biochemical characteristics and differential modulation after feeding. Canadian Journal of Zoology, 96(6), 576–584. https://doi.org/10.1139/cjz-2017-0128
Asaro, A., Martos-Sitcha, J. A., Martínez-Rodríguez, G., Mancera, J. M., & López Mañanes, A. (2018). In silico analysis and effects of environmental salinity in the expression and activity of digestive α-amylase and trypsins from the euryhaline crab Neohelice granulata. Canadian Journal of Zoology, 96(2), 127–139. https://doi.org/10.1139/cjz-2016-0324
Asaro, A., Paggi, R. A., del Valle, J. C., & López Mañanes, A. A. (2018). Glucose homeostasis in the euryhaline crab Cytograpsus angulatus: Effects of the salinity in the amylase, maltase and sucrase activities in the hepatopancreas and in the carbohydrate reserves in different tissues. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 216, 39–47. https://doi.org/10.1016/j.cbpb.2017.11.012
Pinoni, S. A., & López Mañanes, A. A. (2016). Digestive flexibility in the euryhaline crab Cyrtograpsus angulatus (Decapoda, Brachyura, Varunidae) from Mar Chiquita coastal lagoon (Buenos Aires, Argentina): responses to salinity of key enzymes in hepatopancreas. Pan-American Journal of Aquatic Sciences, 11(4), 345–355. Retrieved from http://www.panamjas.org/pdf_artigos/PANAMJAS_11(4)_345-355.pdf
Del Valle, J. C., Michiels, M. S., Radonic, M., López, A., & López Mañanes, A. A. (2016). Digestive and metabolic profile at the biochemical level of juvenile flounder Paralichthys orbignyanus (Valenciennes, 1839) (Pleuronectiformes: Paralichthyidae). Pan-American Journal of Aquatic Sciences, 11(4), 309–323. Retrieved from http://www.panamjas.org/pdf_artigos/PANAMJAS_11(4)_309-323.pdf
Michiels, M. S., del Valle, J. C., & López Mañanes, A. A. (2013). Effect of environmental salinity and dopamine injections on key digestive enzymes in hepatopancreas of the euryhaline crab Cyrtograpsus angulatus (Decapoda: Brachyura: Varunidae. Scientia Marina, 77(1), 129–136. Retrieved from http://ri.conicet.gov.ar/handle/11336/2234
Pinoni, S. A., Méndez, E., & López Mañanes, A. A. (2015). Digestive flexibility in a euryhaline crab from a SW Atlantic coastal lagoon: alkaline phosphatase activity sensitive to salinity in the hepatopancreas. Journal of the Marine Biological Association of the United Kingdom, 95(06), 1133–1140.
Pinoni, S. A., Michiels, M. S., & López Mañanes, A. A. (2013). Phenotypic flexibility in response to environmental salinity in the euryhaline crab Neohelice granulata from the mudflat and the saltmarsh of a SW coastal lagoon. Marine Biology, 160(10), 2647–2661.
Michiels, M. S., del Valle, J. C., & López Mañanes, A. A. (2017). Trypsin and N-aminopeptidase (APN) activities in the hepatopancreas of an intertidal euryhaline crab: Biochemical characteristics and differential modulation by histamine and salinity. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 204, 228–235.
Del Valle, J. C., Acuña, F. H., & López Mañanes, A. A. (2015). Digestive flexibility in response to environmental salinity and temperature in the non-symbiotic sea anemone Bunodosoma zamponii. Hydrobiologia, 759(1), 189–199.
Michiels, M. S., del Valle, J. C., & López Mañanes, A. A. (2015). Lipase activity sensitive to dopamine, glucagon and cyclic AMP in the hepatopancreas of the euryhaline burrowing crab Neohelice granulata (Dana, 1851)(Decapoda, Grapsidae). Crustaceana, 88(1), 51–65. Retrieved from http://booksandjournals.brillonline.com/content/journals/10.1163/15685403-00003399
Michiels, M. S., Del Valle, J. C., & López Mañanes, A. A. (2015). Biochemical characteristics and modulation by external and internal factors of aminopeptidase-N activity in the hepatopancreas of a euryhaline burrowing crab. Journal of Comparative Physiology B, 185(5), 501–510. Retrieved from http://link.springer.com/article/10.1007/s00360-015-0899-3
Investigadores
Investigador asistente CONICET
Pinoni, S. A., Jerez-Cepa, I., López Mañanes, A. A., & Romero, J. M. M. (2018). The euryhaline crab Uca tangeri showed metabolic differences to sex and environmental salinity. Journal of the Marine Biological Association of the United Kingdom, 98(6), 1465–1475. https://doi.org/10.1017/S0025315417000601
Pinoni, S. A., & López Mañanes, A. A. (2016). Digestive flexibility in the euryhaline crab Cyrtograpsus angulatus (Decapoda, Brachyura, Varunidae) from Mar Chiquita coastal lagoon (Buenos Aires, Argentina): responses to salinity of key enzymes in hepatopancreas. Pan-American Journal of Aquatic Sciences, 11(4), 345–355. Retrieved from http://www.panamjas.org/pdf_artigos/PANAMJAS_11(4)_345-355.pdf
Pinoni, S. A., Méndez, E., & López Mañanes, A. A. (2015). Digestive flexibility in a euryhaline crab from a SW Atlantic coastal lagoon: alkaline phosphatase activity sensitive to salinity in the hepatopancreas. Journal of the Marine Biological Association of the United Kingdom, 95(06), 1133–1140.
Pinoni, S. A., Michiels, M. S., & López Mañanes, A. A. (2013). Phenotypic flexibility in response to environmental salinity in the euryhaline crab Neohelice granulata from the mudflat and the saltmarsh of a SW coastal lagoon. Marine Biology, 160(10), 2647–2661.
Becarios
Dra. Antonela Asaro
Becaria CONICET
Asaro, A., Martos-Sitcha, J. A., Martínez-Rodríguez, G., Mancera, J. M., & López Mañanes, A. (2018). In silico analysis and effects of environmental salinity in the expression and activity of digestive α-amylase and trypsins from the euryhaline crab Neohelice granulata. Canadian Journal of Zoology, 96(2), 127–139. https://doi.org/10.1139/cjz-2016-0324
Asaro, A., Paggi, R. A., del Valle, J. C., & López Mañanes, A. A. (2018). Glucose homeostasis in the euryhaline crab Cytograpsus angulatus: Effects of the salinity in the amylase, maltase and sucrase activities in the hepatopancreas and in the carbohydrate reserves in different tissues. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 216, 39–47. https://doi.org/10.1016/j.cbpb.2017.11.012
Dra. María Soledad Michiels
Becaria CONICET
Del Valle, J. C., Michiels, M. S., Radonic, M., López, A., & López Mañanes, A. A. (2016). Digestive and metabolic profile at the biochemical level of juvenile flounder Paralichthys orbignyanus (Valenciennes, 1839) (Pleuronectiformes: Paralichthyidae). Pan-American Journal of Aquatic Sciences, 11(4), 309–323. Retrieved from http://www.panamjas.org/pdf_artigos/PANAMJAS_11(4)_309-323.pdf
Michiels, M. S., del Valle, J. C., & López Mañanes, A. A. (2013). Effect of environmental salinity and dopamine injections on key digestive enzymes in hepatopancreas of the euryhaline crab Cyrtograpsus angulatus (Decapoda: Brachyura: Varunidae. Scientia Marina, 77(1), 129–136. Retrieved from http://ri.conicet.gov.ar/handle/11336/2234
Pinoni, S. A., Michiels, M. S., & López Mañanes, A. A. (2013). Phenotypic flexibility in response to environmental salinity in the euryhaline crab Neohelice granulata from the mudflat and the saltmarsh of a SW coastal lagoon. Marine Biology, 160(10), 2647–2661.
Michiels, M. S., del Valle, J. C., & López Mañanes, A. A. (2017). Trypsin and N-aminopeptidase (APN) activities in the hepatopancreas of an intertidal euryhaline crab: Biochemical characteristics and differential modulation by histamine and salinity. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 204, 228–235.
Michiels, M. S., del Valle, J. C., & López Mañanes, A. A. (2015). Lipase activity sensitive to dopamine, glucagon and cyclic AMP in the hepatopancreas of the euryhaline burrowing crab Neohelice granulata (Dana, 1851)(Decapoda, Grapsidae). Crustaceana, 88(1), 51–65. Retrieved from http://booksandjournals.brillonline.com/content/journals/10.1163/15685403-00003399
Michiels, M. S., Del Valle, J. C., & López Mañanes, A. A. (2015). Biochemical characteristics and modulation by external and internal factors of aminopeptidase-N activity in the hepatopancreas of a euryhaline burrowing crab. Journal of Comparative Physiology B, 185(5), 501–510. Retrieved from http://link.springer.com/article/10.1007/s00360-015-0899-3
Becaria CONICET
Méndez, E., Caruso Neves, C., & López Mañanes, A. (2018). Two sodium pumps in the hepatopancreas of the intertidal euryhaline crab Neohelice granulata: biochemical characteristics and differential modulation after feeding. Canadian Journal of Zoology, 96(6), 576–584. https://doi.org/10.1139/cjz-2017-0128
Pinoni, S. A., Méndez, E., & López Mañanes, A. A. (2015). Digestive flexibility in a euryhaline crab from a SW Atlantic coastal lagoon: alkaline phosphatase activity sensitive to salinity in the hepatopancreas. Journal of the Marine Biological Association of the United Kingdom, 95(06), 1133–1140.