This group of research was created in 2011. It includes some members of the former LICAS Group- Faculty of Exact and Natural Sciences- UNMDP directed by Dr. Víctor J. Moreno  and Dra. Julia E. A. de Moreno. Our group is interested on aquatic ecotoxicology, focusing on effects at biochemical and genetic level in aquatic non target organisms exposed to organic pollutants, like current- use pesticides.

Monitoring of aquatic pollution
Biochemical biomarkers (detoxication and antioxidant enzymes, endogenous metabolites)
Biomarkers of genotoxicity (cytogenetic and molecular)
Molecular biomarkers (isoenzyme expression)

Director    
Dra. Menone Mirta Lujan
Researcher CONICET
Teaching Assistant
Pérez, D. J., Okada, E., Iturburu, F. G., De Gerónimo, E., Cantón, G., Aparicio, V. C., Costa, J. L., & Menone, M. L. (2021). Monensin occurrence in surface water and its impact on aquatic biota in a stream of the southeast Pampas, Argentina. Environmental Science and Pollution Research, 28(7), 8530–8538. https://doi.org/10.1007/s11356-020-11009-2
Crupkin, A. C., Fulvi, A. B., Iturburu, F. G., Medici, S., Mendieta, J., Panzeri, A. M., & Menone, M. L. (2021). Evaluation of hematological parameters, oxidative stress and DNA damage in the cichlid Australoheros facetus exposed to the fungicide azoxystrobin. Ecotoxicology and Environmental Safety, 207, 111286. https://doi.org/10.1016/j.ecoenv.2020.111286
Corcoran, S., Metcalfe, C. D., Sultana, T., Amé, M. V., & Menone, M. L. (2020). Pesticides in surface waters in Argentina monitored using polar organic chemical integrative samplers. Bulletin of Environmental Contamination and Toxicology, 104, 21–26. https://doi.org/10.1007/s00128-019-02758-z
Negro, C. L., Iturburu, F. G., Mendieta, J., Menone, M. L., & Collins, P. (2019). Are oxidative stress biomarkers sensitive to environmental concentrations of chlorpyrifos exposed to the freshwater crab, Zilchiopsis collastinensis (Decapoda; Trichodactylidae)? Bulletin of Environmental Contamination and Toxicology, 103(3), 405–410. https://doi.org/10.1007/s00128-019-02643-9
Moreyra, L. D., Garanzini, D. S., Medici, S., & Menone, M. L. (2019). Evaluation of growth, photosynthetic pigments and genotoxicity in the wetland macrophyte Bidens laevis exposed to tebuconazole. Bulletin of Environmental Contamination and Toxicology, 102(3), 353–357. https://doi.org/10.1007/s00128-019-02539-8
Garanzini, D. S., Medici, S., Moreyra, L. D., & Menone, M. L. (2019). Acute exposure to a commercial formulation of Azoxystrobin alters antioxidant enzymes and elicit damage in the aquatic macrophyte Myriophyllum quitense. Physiology and Molecular Biology of Plants, 25(1), 135–143. https://doi.org/10.1007/s12298-018-0603-7
Iturburu, F. G., Bertrand, L., Mendieta, J. R., Amé, M. V., & Menone, M. L. (2018). An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid. Ecological Indicators, 93, 351–357. https://doi.org/10.1016/j.ecolind.2018.05.019
Crupkin, A. C., Iturburu, F. G., Crupkin, M., & Menone, M. L. (2018). Myofibrilar functional dysregulation in fish: A new biomarker of damage to pesticides. Ecotoxicology and Environmental Safety, 158, 44–49. https://doi.org/10.1016/j.ecoenv.2018.03.096
Lukaszewicz, G., Amé, M. V., & Menone, M. L. (2018). Selection of reference genes for reverse transcription-qPCR analysis in the biomonitor macrophyte <Emphasis Type="Italic">Bidens laevis</Emphasis> L. Physiology and Molecular Biology of Plants, 24(5), 781–792. https://doi.org/10.1007/s12298-018-0534-3
Iturburu, F. G., Simoniello, M. F., Medici, S., Panzeri, A. M., & Menone, M. L. (2018). Imidacloprid causes DNA damage in fish: clastogenesis as a mechanism of genotoxicity. Bulletin of Environmental Contamination and Toxicology, 100(6), 760–764. https://doi.org/10.1007/s00128-018-2338-0
Pérez, D. J., Okada, E., Menone, M. L., & Costa, J. L. (2017). Can an aquatic macrophyte bioaccumulate glyphosate? Development of a new method of glyphosate extraction in Ludwigia peploides and watershed scale validation. Chemosphere, 185, 975–982. https://doi.org/10.1016/j.chemosphere.2017.07.093
Iturburu, F. G., Zömisch, M., Panzeri, A. M., Crupkin, A. C., Contardo-Jara, V., Pflugmacher, S., & Menone, M. L. (2017). Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus. Environmental Toxicology and Chemistry, 36(3), 699–708. http://onlinelibrary.wiley.com/doi/10.1002/etc.3574/full
Menone, M. L., Pérez, D. J., Lukaszewicz, G., & Camadro, E. L. (2015). Identificación de hidrófitas dulceacuícolas para estudios de genotoxicidad de contaminantes acuáticos. Journal of Basic and Applied Genetics, 26(1), 9–17. http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332015000100002
Garanzini, D. S., & Menone, M. L. (2015). Azoxystrobin causes oxidative stress and DNA damage in the aquatic macrophyte Myriophyllum quitense. Bulletin of Environmental Contamination and Toxicology, 94(2), 146–151. http://link.springer.com/article/10.1007/s00128-014-1428-x
Salvio, C., Manetti, P. L., Clemente, N. L., Menone, M. L., & López, A. N. (2015). Toxicidad subletal de clorpirifos sobre Octolasion cyaneum (Annelida: Oligochaeta, Lumbricidae). Agriscientia, 32(2), 131–138. http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1668-298X2015000200006
Débora J. Pérez, Lukaszewicz, G., Menone, M. L., Amé, M. V., & Camadro, E. L. (2014). Genetic and biochemical biomarkers in the macrophyte Bidens laevis L. exposed to a commercial formulation of endosulfan. Environmental Toxicology, 29(9), 1063–1071. http://onlinelibrary.wiley.com/doi/10.1002/tox.21836/full
Crupkin, A. C., Carriquiriborde, P., Mendieta, J., Panzeri, A. M., Ballesteros, M. L., Miglioranza, K. S., & Menone, M. L. (2013). Oxidative stress and genotoxicity in the South American cichlid, Australoheros facetus, after short-term sublethal exposure to endosulfan. Pesticide Biochemistry and Physiology, 105(2), 102–110. http://www.sciencedirect.com/science/article/pii/S0048357512001861
Crupkin, A. C., & Menone, M. L. (2013). Changes in the activities of glutathione-S-transferases, glutathione reductase and catalase after exposure to different concentrations of cadmium in Australoheros facetus (Cichlidae, Pisces). Ecotoxicology and Environmental Contamination, 8(1), 21–25. http://siaiap32.univali.br/seer/index.php/eec/article/view/3152
Menone, M. L., Iturburu, F. G., Demetrio, P. M., Venturino, A., Pedrozo, F. L., Temporetti, P. F., Rodríguez, A., Amé, M. V., Quaini, K. P., & Collins, P. A. (n.d.). Calidad del agua y niveles guía para la protección de la biodiversidad acuática. Interacción entre ciencia y gestión. Ecología Austral. Retrieved July 20, 2021, from http://ojs.ecologiaaustral.com.ar/index.php/Ecologia_Austral/article/view/1722
Researchers    
Dra. Crupkin Andrea Carina
Researcher CIC
Professor
Crupkin, A. C., Fulvi, A. B., Iturburu, F. G., Medici, S., Mendieta, J., Panzeri, A. M., & Menone, M. L. (2021). Evaluation of hematological parameters, oxidative stress and DNA damage in the cichlid Australoheros facetus exposed to the fungicide azoxystrobin. Ecotoxicology and Environmental Safety, 207, 111286. https://doi.org/10.1016/j.ecoenv.2020.111286
Crupkin, A. C., Iturburu, F. G., Crupkin, M., & Menone, M. L. (2018). Myofibrilar functional dysregulation in fish: A new biomarker of damage to pesticides. Ecotoxicology and Environmental Safety, 158, 44–49. https://doi.org/10.1016/j.ecoenv.2018.03.096
Iturburu, F. G., Zömisch, M., Panzeri, A. M., Crupkin, A. C., Contardo-Jara, V., Pflugmacher, S., & Menone, M. L. (2017). Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus. Environmental Toxicology and Chemistry, 36(3), 699–708. http://onlinelibrary.wiley.com/doi/10.1002/etc.3574/full
Crupkin, A. C., Carriquiriborde, P., Mendieta, J., Panzeri, A. M., Ballesteros, M. L., Miglioranza, K. S., & Menone, M. L. (2013). Oxidative stress and genotoxicity in the South American cichlid, Australoheros facetus, after short-term sublethal exposure to endosulfan. Pesticide Biochemistry and Physiology, 105(2), 102–110. http://www.sciencedirect.com/science/article/pii/S0048357512001861
Crupkin, A. C., & Menone, M. L. (2013). Changes in the activities of glutathione-S-transferases, glutathione reductase and catalase after exposure to different concentrations of cadmium in Australoheros facetus (Cichlidae, Pisces). Ecotoxicology and Environmental Contamination, 8(1), 21–25. http://siaiap32.univali.br/seer/index.php/eec/article/view/3152
Dr. Iturburu Fernando Gastón
Researcher CONICET

Pérez, D. J., Okada, E., Iturburu, F. G., De Gerónimo, E., Cantón, G., Aparicio, V. C., Costa, J. L., & Menone, M. L. (2021). Monensin occurrence in surface water and its impact on aquatic biota in a stream of the southeast Pampas, Argentina. Environmental Science and Pollution Research, 28(7), 8530–8538. https://doi.org/10.1007/s11356-020-11009-2
Crupkin, A. C., Fulvi, A. B., Iturburu, F. G., Medici, S., Mendieta, J., Panzeri, A. M., & Menone, M. L. (2021). Evaluation of hematological parameters, oxidative stress and DNA damage in the cichlid Australoheros facetus exposed to the fungicide azoxystrobin. Ecotoxicology and Environmental Safety, 207, 111286. https://doi.org/10.1016/j.ecoenv.2020.111286
Negro, C. L., Iturburu, F. G., Mendieta, J., Menone, M. L., & Collins, P. (2019). Are oxidative stress biomarkers sensitive to environmental concentrations of chlorpyrifos exposed to the freshwater crab, Zilchiopsis collastinensis (Decapoda; Trichodactylidae)? Bulletin of Environmental Contamination and Toxicology, 103(3), 405–410. https://doi.org/10.1007/s00128-019-02643-9
Iturburu, F. G., Bertrand, L., Mendieta, J. R., Amé, M. V., & Menone, M. L. (2018). An integrated biomarker response study explains more than the sum of the parts: Oxidative stress in the fish Australoheros facetus exposed to imidacloprid. Ecological Indicators, 93, 351–357. https://doi.org/10.1016/j.ecolind.2018.05.019
Crupkin, A. C., Iturburu, F. G., Crupkin, M., & Menone, M. L. (2018). Myofibrilar functional dysregulation in fish: A new biomarker of damage to pesticides. Ecotoxicology and Environmental Safety, 158, 44–49. https://doi.org/10.1016/j.ecoenv.2018.03.096
Iturburu, F. G., Simoniello, M. F., Medici, S., Panzeri, A. M., & Menone, M. L. (2018). Imidacloprid causes DNA damage in fish: clastogenesis as a mechanism of genotoxicity. Bulletin of Environmental Contamination and Toxicology, 100(6), 760–764. https://doi.org/10.1007/s00128-018-2338-0
Iturburu, F. G., Zömisch, M., Panzeri, A. M., Crupkin, A. C., Contardo-Jara, V., Pflugmacher, S., & Menone, M. L. (2017). Uptake, distribution in different tissues, and genotoxicity of imidacloprid in the freshwater fish Australoheros facetus. Environmental Toxicology and Chemistry, 36(3), 699–708. http://onlinelibrary.wiley.com/doi/10.1002/etc.3574/full
Menone, M. L., Iturburu, F. G., Demetrio, P. M., Venturino, A., Pedrozo, F. L., Temporetti, P. F., Rodríguez, A., Amé, M. V., Quaini, K. P., & Collins, P. A. (n.d.). Calidad del agua y niveles guía para la protección de la biodiversidad acuática. Interacción entre ciencia y gestión. Ecología Austral. Retrieved July 20, 2021, from http://ojs.ecologiaaustral.com.ar/index.php/Ecologia_Austral/article/view/1722
Graduate Students    
Dra. Villagran Diana Mariel
Posdoctoral Fellow

Lic. Lombardero Lucas Rodrigo
Doctoral Fellow – CONICET